PD Dr Valerij G. Kiselev | Diffusion MRI -- Quo vadis?

Gastvortrag

  • Datum: 02.08.2017
  • Uhrzeit: 15:00 - 16:00
  • Vortragende(r): PD Dr Valerij G. Kiselev
  • Department of Radiology Medical Physics University Medical Center Freiburg Germany
  • Ort: MPI für Kognitions- und Neurowissenschaften
  • Raum: Wilhelm Wundt Raum (A400)
  • Gastgeber: Neurophysik
  • Kontakt: kiselev@ukl.uni-freiburg.de
The microstructural MRI is now booming experiencing an exponential increase in the number of publications and diffusion MRI is on the forefront of this development. The dawn of diffusion MRI was celebrated with the success of detecting the infarct core in acute stroke. The next success in the beginning of the 2000s was the development of fiber tracking. The hall of fame of diffusion MRI did not include however any further doubtless member. The development in the 2010s has rather demonstrated a number of pitfalls on the tortuous way to accessing the tissue microstructure, the new paramount goal of diffusion MRI, sometimes expressed as "in-vivo MRI histology". The hope to achieve this goal takes its origin in the fact that the typical diffusion length of water molecules during an MRI signal acquisition is commensurate with the cell size. The challenge here is trace what happens to the imprint of cellular features in the massive averaging of signal on the subvoxel scale due to the macroscopic resolution of MRI, which is two -- three orders of magnitude coarser than the cell size. This brings research in realm of (soft) condensed matter physics, away from the paradigm of the early days of MRI, "new contrast -- new sequence -- new clinical application", all in the same study. This talk focuses on the analysis of the big challenge that diffusion MRI has to respond to, the pitfalls on the way and the most recently proposed ways to proceed.

Poster
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