Juliane Damm | Towards a comprehensive microstructural human connectome (COMIC): from long-range to short association fibres

Project Presentation (internal)

  • Date: Mar 13, 2023
  • Time: 02:30 PM - 03:00 PM (Local Time Germany)
  • Speaker: Juliane Damm
  • Department of Neurophysics
  • Location: MPI for Human Cognitive and Brain Sciences
  • Room: Lecture Hall (C101) + Zoom Meeting (hybrid mode)
  • Host: Department of Neurophysics
Current estimates of the human structural connectome are based on Diffusion-Weighted Imaging (DWI) and suffer from some incompleteness and biases. Particularly, short association fibres (SAF), making up 90% of all white matter connections, are underrepresented. Furthermore, functionally relevant microstructural fibre properties that impact conduction efficiency and velocity are missing. State-of-the-art high-resolution DWI in combination with tailored pre-processing pipelines allows robust mapping of SAF. Quantitative magnetic resonance imaging (qMRI) and advanced DWI provides unique insights into the microstructural properties of white matter, including myelination, iron content and measures sensitive to g-ratio. In this project we aim to generate a more comprehensive human microstructural connectome across the adult life span combining ultra-high-resolution qMRI and advanced DWI. This new connectome will, for the first time, incorporate both, short cortico-cortical, and long-range connections together with microstructural information from cortex and white matter tracts across the adult life span.
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