PhD Shir Filo | Increasing the molecular specificity of quantitative MRI
Institute Colloquium (internal)
- Date: Dec 2, 2024
- Time: 03:00 PM - 04:00 PM (Local Time Germany)
- Speaker: PhD Shir Filo
- The Edmond & Lily Safra Center for Brain Sciences, Israel / Max Planck Institute for Human Cognitive and Brain Sciences, Germany
- Location: MPI for Human Cognitive and Brain Sciences
-
Room:
Lecture Hall (C101) + Zoom Meeting (hybrid mode)
https://zoom.us/j/94651679346?pwd=VWErd1hTc0ZnanBuQjYyWXF6Ti9TUT09 Meeting ID: 946 5167 9346 Passcode: 361703 - Host: Department of Neurophysics
- Contact: amuehlberg@cbs.mpg.de
Abstract: Comprehensive description of brain tissue's microstructure is crucial for studying the normal and diseased brain. In the talk I will present an in-vivo biophysical framework for increasing the specificity of quantitative MRI to distinct microstructural features of brain tissue, such as the lipid composition and the iron homeostasis. This non-invasive method identifies lipid-related changes in the aging human brain, providing a way to test various theories of aging. Additionally, it reveals the disrupted iron homeostasis in brain tumors, and provides iron-related information inaccessible by conventional MRI approaches. Finally, I will propose a new MRI protocol, for implementing this qMRI approach at the sub-voxel level. By monitoring microstructural processes in living brains, the proposed biophysical framework provides a new level of quantitative characterization of brain tissue, paving the way for advancements in understanding both normal physiology and pathology in human brain research.
Abstract: Comprehensive description of brain tissue's microstructure is crucial for studying the normal and diseased brain.
In the talk I will present an in-vivo biophysical framework for increasing the specificity of quantitative MRI to distinct microstructural features of brain tissue, such as the lipid composition and the iron homeostasis. This non-invasive method identifies lipid-related changes in the aging human brain, providing a way to test various theories of aging. Additionally, it reveals the disrupted iron homeostasis in brain tumors, and provides iron-related information inaccessible by conventional MRI approaches. Finally, I will propose a new MRI protocol, for implementing this qMRI approach at the sub-voxel level. By monitoring microstructural processes in living brains, the proposed biophysical framework provides a new level of quantitative characterization of brain tissue, paving the way for advancements in understanding both normal physiology and pathology in human brain research.