Head

Dr. Daniel S. Margulies
Dr. Daniel S. Margulies
Research group leader
Phone: +49 341 9940-2612

Contact

Dr. Natacha Mendes
Dr. Natacha Mendes
Scientific assistant
Phone: +49 341 9940-2486
Fax: +49 341 9940-2221

Independent Research Groups

Max Planck Research Group "Neuroanatomy & Connectivity"

The prefrontal cortex is a densely interconnected and functionally complex region that has evaded a coherent, generally accepted model of function. Our research agenda aims to characterize its connectivity and organization, and does so by branching into three interwoven topics:

  1. cortical organization, primary as described by intrinsic functional connectivity;
  2. its relationship to self-generated thought;
  3. the modulation of functional brain organization by changes in higher-order internal frameworks that constitute an individual’s identity.

Our current line of research expands these themes to more generally investigate the emergence of network topology across association cortex. We integrate cortical surface mapping techniques with models of cortical development to explore how the morphology of the cortex gives rise to the network structures we observe.

Selected Projects

In a complex environment, adaptive cognition emerges through an appropriate balance of information from immediate sensory input and information representative of long-term goals.

Connectomic correlates of self-generated thought

In a complex environment, adaptive cognition emerges through an appropriate balance of information from immediate sensory input and information representative of long-term goals. [more]
Delineating the distinct cortical fields within the human prefrontal cortex (PFC), and their connectivity patterns, offers substantial challenges. Histological analysis of the macaque monkey PFC provides the gold standard for the cytoarchitectonic and connectional architecture

Parcellation of prefrontal cortex in macaques and humans

Delineating the distinct cortical fields within the human prefrontal cortex (PFC), and their connectivity patterns, offers substantial challenges. Histological analysis of the macaque monkey PFC provides the gold standard for the cytoarchitectonic and connectional architecture [more]
The vast majority of studies in human cognitive neuroscience are built upon assumptions supported by previous research. In MRI-based studies, those are often used to improve the power

Bridging the gap between exploratory and hypothesis-driven brain analyses by collecting and incorporating prior knowledge

The vast majority of studies in human cognitive neuroscience are built upon assumptions supported by previous research. In MRI-based studies, those are often used to improve the power [more]
The research approaches of the humanities and social sciences offer a unique vantage to investigate the emergence, characteristics and challenges facing the nascent field of resting-state fMRI.

Tracking the fields of resting-state and mind-wandering

The research approaches of the humanities and social sciences offer a unique vantage to investigate the emergence, characteristics and challenges facing the nascent field of resting-state fMRI. [more]
Methodological advances in structural, diffusion-based, and functional MRI have increased the resolution of data describing the degree of connectedness between cortical areas.

Visualization of cortical connectivity

Methodological advances in structural, diffusion-based, and functional MRI have increased the resolution of data describing the degree of connectedness between cortical areas. [more]
In the context of neuroimaging studies, large sample sizes of diverse multi-modal participant data correlated with MR data sets offer the possibility to explore novel relationships.

Incorporating XNAT into the data management and processing infrastructure

In the context of neuroimaging studies, large sample sizes of diverse multi-modal participant data correlated with MR data sets offer the possibility to explore novel relationships. [more]
 
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