Max Planck Research Group Adaptive Memory

Humans possess the remarkable capacity to vividly remember a plethora of experiences from their lives. They can voluntarily reminisce about cherished moments but also be haunted by intrusive memories of unpleasant experiences. At the heart of the research in the Adaptive Memory Group is the insight that memory is not merely a passive capacity but a constructive process. As such, memories, on one hand, are malleable to change and disruption but, on the other hand, can also be recombined into novel experiences. We seek to understand the nature of adaptive memory by using behavioral, fMRI, and neuromodulation methods, and by examining cognitive functions in patients with focal brain lesions. In particular, we focus on three intertwined research areas:

 

(i) Memory suppression

The work on voluntary forgetting seeks to understand the different neurocognitive mechanisms underlying the ability to suppress unwanted memories. We have reported evidence for two opposing mechanisms that can achieve memory suppression (Benoit & Anderson, 2012): one by effectively shutting down hippocampal retrieval processes (i.e., direct suppression) and the other by guiding hippocampal retrieval towards the recollection of alternative memories that then keep the unwanted memory out of awareness (i.e., thought substitution). I examine how these mechanisms can be adaptively recruited to purge intrusive memories from consciousness (Benoit et al., 2015), and how they are compromised in clinical populations that are characterized by deficits in controlling unwanted thoughts (Stramaccia et al., in press; Kupper, Benoit, et al., 2014). We further examine how a mechanism akin to direct suppression can also be engaged to control persistent imaginings of future fears (Benoit, Davies, & Anderson, in 2016) (see also ii).


Key publications:


Stramaccia, D.; Rischer, K. M.; Fawcett , J. M.; Benoit, R. G.: Memory suppression and its deficiency in psychological disorders: A focused meta-analysis. Journal of Experimental Psychology: General (2020)
Benoit, R.G., Davies, D.J., & Anderson, M.C.
Reducing future fears by suppressing the brain mechanisms underlying episodic simulation.
Proceedings of the National Academy of Sciences of the USA
Benoit, R.G., Hulbert, J.C., Huddleston, E., & Anderson, M.C.
Adaptive top-down suppression of hippocampal activity and the purging of intrusive memories from consciousness.
Journal of Cognitive Neuroscience  27(1), 96-111, 2015
Benoit, R.G., & Anderson, M.C.
Opposing mechanisms support the voluntary forgetting of unwanted memories.
Neuron 76(2), 450-460, 2012

(ii) Episodic simulation

The work on episodic simulation examines the core brain network involved in recollecting the past and imagining the future (Benoit & Schacter, 2015), with an emphasis on medial prefrontal cortex and the hippocampus (Benoit, Szpunar, & Schacter, 2014). It seeks to elucidate the mechanisms by which imagining the future can bias decisions towards more farsighted outcomes (Benoit, Gilbert, & Burgess, 2011). In recent work, we have also provided evidence that mere simulations can induce learning much in the same way as actual experiences, thus shaping our real-life attitudes and models of the world (Benoit, Paulus, & Schacter, 2019). However, despite the clear adaptive value of envisaging the future, dwelling too much on the future may also have aversive consequences. We examine how, in such situations, the mechanisms involved in memory suppression get also engaged to effectively stop imagining (Benoit, Davies, & Anderson, 2016; see also i).


Key publications:


Benoit, R. G.; Paulus, P. C.; Schacter, D. L.: Forming attitudes via neural activity supporting affective episodic simulations. Nature Communications 10, 2215 (2019)
Benoit, R.G., Schacter, D.L.
Specifying the core network supporting episodic simulation and episodic memory by activation likelihood estimation.
Neuropsychologia 75, 450-457, 2015
Benoit, R.G., Szpunar, K.K., Schacter, D.L.
Ventromedial prefrontal cortex supports affective future simulation by integrating distributed knowledge.
Proceedings of the National Academy of Sciences of the USA 111(46), 16550-16555, 2014
Benoit, R.G., Gilbert, S.J., Burgess, P.W.
A neural mechanism mediating the impact of episodic prospection on farsighted decisions.
The Journal of Neuroscience 31(18), 6771-6779, 2011

(iii) Prefrontal cortex functioning

This work focuses on the memory functions of the medial prefrontal cortex (PFC). We have provided evidence that this region codes for affective representations of our environment (e.g., of familiar people and places) that can be flexibly engaged for the simulation of possible future events (Benoit et al., 2011; 2014; 2019; Paulus et al., under review). We currently seek to understand the interactions of this region with the medial temporal lobes, both in the service of retrieving individual episodic memories and for the formation of affective memory schemas. In addition, our research on suppression adds to our understanding of the lateral PFC by showing how its subregions influence processing in other parts of the brain, notably the hippocampus (Benoit & Anderson, 2012; Benoit et al., 2015). Further research is targeted at determining the functional organization of rostral prefrontal cortex, i.e., the most anterior part of the brain (e.g., Benoit, et al., 2010; 2012).


Key publications (in addition to those listed above):


Paulus, P. C.; Charest, I.; Benoit, R. G.: Revealing the structure of affective schematic representations in the medial prefrontal cortex. bioRxiv (2020)
Benoit, R.G., Gilbert, S.J., Frith, C.D., Burgess, P.W.
Rostral prefrontal cortex and the focus of attention in prospective memory.
Cerebral Cortex 22(8), 1876-1886, 2012
Benoit, R.G., Gilbert, S.J., Volle E., Burgess, P.W.
When I think about me and simulate you: Medial rostral prefrontal cortex and self-referential processes.
NeuroImage 50(3), 1340-1349, 2010

 

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