Influence of Anisotropic Conductivity on EEG/MEG Source Localization

To achieve a deeper understanding of the brain, scientists and clinicians use Electroencephalography (EEG) and Magnetoencephalography (MEG) inverse methods to reconstruct sources in the cortical sheet of the human brain. The influence of structural and electrical anisotropy in both skull and white matter on EEG and MEG source reconstruction are not well understood. We study of the sensitivity to tissue anisotropy of the EEG/MEG forward and inverse problem in an anatomically accurate model of the human head. The anisotropy of skull and white matter conductivity compromises the EEG forward potential computation and as a consequence, the inverse source reconstruction. For MEG, only the anisotropy of the white matter compartment has a significant effect.

Selected Publications

Carsten Hermann Wolters, Alfred Anwander, X. Tricoche, D. Weinstein, Martin A. Koch, and R. S. MacLeod, "Influence of tissue conductivity anisotropy on EEG/MEG field and return current computation in a realistic head model: A simulation and visualization study using high-resolution finite element modeling," NeuroImage 30 (3), 813-826 (2006).
Go to Editor View