Deterministic and Probabilistic Tractography based on Complex Fiber Orientation Distributions


  • Development of local models for fibre orientation distribution, accounting for crossing and fanning structures.
  • Development of effective deterministic and probabilistic fibre tracking algorithms. In order to improve the applicability of the techniques, we realize speed effective implementation using parallelization.
  • Systematic comparison of a broad selection of current state-of-the-art fibre tracking algorithms.
  • Application to various cognitive systems.

People currently involved

  • Alfred Anwander (responsible)
  • Till Riffert
  • Jan Schreiber
  • Thomas Knösche

External cooperations

  • Neurospin Paris (Maxime Descoteaux, Pierre Fillard, Cyril Poupon)
  • MPI for Neurological Research Cologne (Marc Tittgemeyer, Nico Gorbach)
  • MPI for Human Cognitive and Neurosciences (Robin Heidemann, Robert Turner, Angela Friederici, Marco Taubert, Arno Villringer, Karsten Müller, Jens Brauer, Helen Blank, Katharina von Kriegstein)
  • University of Lausanne (Bogdan Draganski)

Publications (peer reviewed)

  • M. Descoteaux, A. Anwander, T.R. Knösche, R. Deriche (2009): Deterministic and Probabilistic Tractography based on Complex Fiber Orientation Distributions, IEEE-Transactions on Medical Imaging, 28, 269-286
  • E. Kaden, A. Anwander, T.R. Knösche (2008): Variational Inferences of the Fiber Orientation Density using Diffusion MR Imaging, NeuroImage 42, 1366-1380
  • E. Kaden, T.R. Knösche, A. Anwander (2007): Bayesian analyis of anatomical connectivity using diffusion MRI, NeuroImage 27(2), 474-488
  • T.-S.Yo, A. Anwander, M. Descoteaux, P. Fillard, C. Poupon, T.R. Knösche, Quantify Brain Connectivity: A Comparative Study of Tractography. MICCAI 2009, Proceedings, Part I, Lecture Notes in Computer Science 5761, pp. 886-893, 2009.
  • R.M. Heidemann, A. Anwander, T. Feiweier, T.R. Knösche, R. Turner (accepted): k-space and q-space: Combining ultrahigh spatial and angular resolution in diffusion imaging using ZOOPPA at 7T. NeuroImage
  • Taubert, M., Draganski, B., Anwander, A., Mueller, K., Horstmann, A., Villringer, A., & Ragert, P. (2010). Dynamic properties of human brain structure: Learning-related changes in cortical areas and associated fiber connections. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 30(35), 11670-11677. doi:10.1523/JNEUROSCI.2567-10.2010.
  • Brauer, J., Anwander, A., & Friederici, A. D. (2011). Neuroanatomical prerequisites for language functions in the maturing brain. Cerebral Cortex, 21(2), 459-466. doi:10.1093/cercor/bhq108.
  • Calamante, F., Tournier, J.-D., Heidemann, R. M., Anwander, A., Jackson, G. D., & Conelly, A. (2011). Track density imaging (TDI): validation of super resolution property. NeuroImage, 56(3),1259-1266. doi:10.1016/j.neuroimage.2011.02.059.
  • Blank, H., Anwander, A., & von Kriegstein, K. (2011). Direct structural connections between voice and face-recognition areas. The Journal of Neuroscience, 31(36), 12906-12915. doi:10.1523/JNEUROSCI.2091-11.2011.
  • Perani, D., Saccuman, M. C., Scifo, P., Anwander, A., Spada, D., Baldoli, C., Poloniato, A., Lohmann, G., & Friederici, A. D. (2011). The neural language networks at birth. Proceedings of the National Academy of Sciences of the United States of America, 108(38), 16056-16061. doi:10.1073/pnas.1102991108.
  • Fillard, P., Descoteaux, M., Goh, A., Gouttard, S., Jeurissen, B., Malcolm, J., Ramirez-Manzanares, A., Reisert, M., Sakaie, K., Tensaouti, F., Yo, T.-S., Mangin, J.-F., & Poupon, C. (2011). Quantitative evaluation of 10 tractography algorithms on a realistic diffusion MR phantom. Neuroimage, 56(1), 220-234. doi:10.1016/j.neuroimage.2011.01.032.
  • Mueller, K., Anwander, A., Möller, H. E., Horstmann, A., Lepsien, J., Busse, F. P., Mohammadi, S., Schroeter, M. L., Stumvoll, M., Villringer, A., & Pleger, B. (2011). Sex-dependent influences of obesity on cerebral white matter investigated by diffusion-tensor imaging. Plos One, 6(4). doi:10.1371/journal.pone.0018544.

Selected conference contributions

  • Probabilistic Q-Ball Tractography Solves Crossings of Callosal Fibers, 2007, Anwander, Alfred; Descoteaux, Maxime; Deriche, Rachid; 13th Annual Meeting of the Organization For Human Brain Mapping, Chicago, USA, Poster 342 T-PM.
  • Deterministic and Probabilistic Q-Ball Tractography: from Diffusion to Sharp Fiber Distributions, 2007, Maxime Descoteaux, Rachid Deriche, Alfred Anwander, Research Report INRIA, France
  • Friederici, A.D.; Bahlmann, J.; Heim, S.; Schubotz, R.I.; Anwander, A. (2006). The brain differentiates human and non-human grammars: Functional localization and structural connectivity Proceedings of the National Academy of Sciences of the United States of America, PNAS, 103 (7), 2458-2463.
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