Deterministic and Probabilistic Tractography based on Complex Fiber Orientation Distributions

Keypoints

Development of local models for fibre orientation distribution, accounting for crossing and fanning structures.
Development of effective deterministic and probabilistic fibre tracking algorithms. In order to improve the applicability of the techniques, we realize speed effective implementation using parallelization.
Systematic comparison of a broad selection of current state-of-the-art fibre tracking algorithms.
Application to various cognitive systems.

People currently involved

Alfred Anwander (responsible)
Till Riffert
Jan Schreiber
Thomas Knösche

External cooperations

Neurospin Paris (Maxime Descoteaux, Pierre Fillard, Cyril Poupon)
MPI for Neurological Research Cologne (Marc Tittgemeyer, Nico Gorbach)
MPI for Human Cognitive and Neurosciences (Robin Heidemann, Robert Turner, Angela Friederici, Marco Taubert, Arno Villringer, Karsten Müller, Jens Brauer, Helen Blank, Katharina von Kriegstein)
University of Lausanne (Bogdan Draganski)

Publications (peer reviewed)

M. Descoteaux, A. Anwander, T.R. Knösche, R. Deriche (2009): Deterministic and Probabilistic Tractography based on Complex Fiber Orientation Distributions, IEEE-Transactions on Medical Imaging, 28, 269-286
E. Kaden, A. Anwander, T.R. Knösche (2008): Variational Inferences of the Fiber Orientation Density using Diffusion MR Imaging, NeuroImage 42, 1366-1380
E. Kaden, T.R. Knösche, A. Anwander (2007): Bayesian analyis of anatomical connectivity using diffusion MRI, NeuroImage 27(2), 474-488
T.-S.Yo, A. Anwander, M. Descoteaux, P. Fillard, C. Poupon, T.R. Knösche, Quantify Brain Connectivity: A Comparative Study of Tractography. MICCAI 2009, Proceedings, Part I, Lecture Notes in Computer Science 5761, pp. 886-893, 2009.
R.M. Heidemann, A. Anwander, T. Feiweier, T.R. Knösche, R. Turner (accepted): k-space and q-space: Combining ultrahigh spatial and angular resolution in diffusion imaging using ZOOPPA at 7T. NeuroImage
Taubert, M., Draganski, B., Anwander, A., Mueller, K., Horstmann, A., Villringer, A., & Ragert, P. (2010). Dynamic properties of human brain structure: Learning-related changes in cortical areas and associated fiber connections. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 30(35), 11670-11677. doi:10.1523/JNEUROSCI.2567-10.2010.
Brauer, J., Anwander, A., & Friederici, A. D. (2011). Neuroanatomical prerequisites for language functions in the maturing brain. Cerebral Cortex, 21(2), 459-466. doi:10.1093/cercor/bhq108.
Calamante, F., Tournier, J.-D., Heidemann, R. M., Anwander, A., Jackson, G. D., & Conelly, A. (2011). Track density imaging (TDI): validation of super resolution property. NeuroImage, 56(3),1259-1266. doi:10.1016/j.neuroimage.2011.02.059.
Blank, H., Anwander, A., & von Kriegstein, K. (2011). Direct structural connections between voice and face-recognition areas. The Journal of Neuroscience, 31(36), 12906-12915. doi:10.1523/JNEUROSCI.2091-11.2011.
Perani, D., Saccuman, M. C., Scifo, P., Anwander, A., Spada, D., Baldoli, C., Poloniato, A., Lohmann, G., & Friederici, A. D. (2011). The neural language networks at birth. Proceedings of the National Academy of Sciences of the United States of America, 108(38), 16056-16061. doi:10.1073/pnas.1102991108.
Fillard, P., Descoteaux, M., Goh, A., Gouttard, S., Jeurissen, B., Malcolm, J., Ramirez-Manzanares, A., Reisert, M., Sakaie, K., Tensaouti, F., Yo, T.-S., Mangin, J.-F., & Poupon, C. (2011). Quantitative evaluation of 10 tractography algorithms on a realistic diffusion MR phantom. Neuroimage, 56(1), 220-234. doi:10.1016/j.neuroimage.2011.01.032.
Mueller, K., Anwander, A., Möller, H. E., Horstmann, A., Lepsien, J., Busse, F. P., Mohammadi, S., Schroeter, M. L., Stumvoll, M., Villringer, A., & Pleger, B. (2011). Sex-dependent influences of obesity on cerebral white matter investigated by diffusion-tensor imaging. Plos One, 6(4). doi:10.1371/journal.pone.0018544.

Selected conference contributions

Probabilistic Q-Ball Tractography Solves Crossings of Callosal Fibers, 2007, Anwander, Alfred; Descoteaux, Maxime; Deriche, Rachid; 13th Annual Meeting of the Organization For Human Brain Mapping, Chicago, USA, Poster 342 T-PM.
Deterministic and Probabilistic Q-Ball Tractography: from Diffusion to Sharp Fiber Distributions, 2007, Maxime Descoteaux, Rachid Deriche, Alfred Anwander, Research Report INRIA, France
Friederici, A.D.; Bahlmann, J.; Heim, S.; Schubotz, R.I.; Anwander, A. (2006). The brain differentiates human and non-human grammars: Functional localization and structural connectivity Proceedings of the National Academy of Sciences of the United States of America, PNAS, 103 (7), 2458-2463.