Connectivity-Based Cortex Parcellation


  • Parcellation of the cortical sheet on the basis of probabilistic tractograms. The similarity matrix of the tractograms is subjected to a clustering algorithm and the results are mapped back on the cortical surface.
  • Effective use of modern tractography and local modelling techniques.
  • Development of new effective hierarchical clustering algorithms.
  • Development of effective measures for the quality of parcellations. They should reflect sharpness of the boundaries and internal homogeneity of patches.
  • Comparison with other parcellation methods.
  • Application to various areas of the cortex.

People currently involved

  • Alfred Anwander (responsible)
  • David Moreno Dominguez
  • Thomas Knösche

External cooperations

  • University of Capetown (Tania Douglas)
  • MPI for Neurological Research Cologne (Christoph Schütte, Nico Gorbach, Corina Meltzer, Marc Tittgemeyer)

Publications (peer reviewed)

  • T.R. Knösche and M. Tittgemeyer: The role of Long-Range Connectivity for the Characterization of the Functional-Anatomical Organization of the Cortex, Frontiers in System Neuroscience 5:58. Epub 2011 Jul 7 (2011)
  • R.I. Schubotz, A. Anwander, T.R. Knösche, D.Y. von Cramon, M. Tittgemeyer: Connectivity-Based Parcellation of the Precentral Gyrus, NeuroImage 50, 396-408 (2010)
  • Anwander, A.; Tittgemeyer, M.; von Cramon, D.Y. ; Friederici, A.D.; Knösche, T.R. (2007). Connectivity-Based Parcellation of Broca's Area. Cerebral Cortex, Volume 17, Number 4, pp. 816-825, Advance Access published May 17, 2006.
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