Women are the majority of patients who are prescribed antidepressants – two out of three patients who have been prescribed a drug for depression are female. Some of these antidepressants are thought to help with motor recovery after stroke. While age-specific stroke rates are higher in men, women experience more frequent and more severe stroke events, and are less likely to recover. But in many pre-clinical trials it is still mainly male participants who are tested, although there is clear evidence of sex-specific differences in disease and the response to medication. In order to bridge this gap neuroscientists around Julia Sacher from the Max-Planck-Institute for Human Cognitive and Brain Sciences have tested 64 healthy women, to see how their brain reacts to the combination of motor learning while taking a common antidepressant. Surprisingly, and in contrast to previous clinical trials, they found no improvement in motor learning among the participants.