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In vivo MRI at mesoscopic resolution (0.1-0.5 mm) enables detailed visualization of the brain’s angioarchitecture, which can be examined across multiple spatial scales, including (1) leptomeningeal vessels, (2) pial vessels, and (3) intracortical vessels. Recently, using multi-shot, multi-echo 3D EPI with T2* contrast, we have achieved substantial advances in imaging the venous angioarchitecture in living humans at 0.35 mm isotropic resolution. Our optimized imaging protocol provides whole-brain coverage in under seven minutes, making the mesoscopic angioarchitecture imaging both feasible and practicable for a wide range of neuroimaging studies. Additionally, we have developed novel processing and analysis methods to enhance visualization and quantification of vascular structures across spatial scales. The combination of our imaging and analysis advancements open new opportunities for studying cerebrovascular function in relation to cortical layers and columns, as well as for anatomical investigations in developmental and clinical research. [more]

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Despite the vital role of scientific software, it remains an overlooked part of research, often developed within short funding periods with little support for long-term maintenance. This results in software that is hard to discover and challenging to install. It also lacks interoperability across different computing systems, hindering its reuse and violating the FAIR principles - which advocate for scientific outputs to be Findable, Accessible, Interoperable, and Reusable. In this talk, I will present our attempts at this problem through the Neurodesk.org project, and I will show what we are planning next. [more]

Scrutiny of the cortical neuronal circuits underlying human visual perception typically involves the summarization of large-scale recordings of brain activity under different perceptual states, with the combination of various measurement modalities and modeling techniques being critical in revealing organizing principles. In this seminar, we'll delve into the relationship between anatomical structure and evolving patterns of neuronal functional connectivity across the early visual foveal cluster (V1-V2-V3). I will show how we can inform our understanding of visual perception through different recording modalities, combining high-resolution fMRI and laminar electrophysiology with computational modeling. I will present key findings on task-dependent modulation of directed interactions across visual cortical areas in humans and laminar distinctions in visual processing in Macaque, as well as touch on preliminary validation work. Finally, I look forward to discussing new advancements and techniques and to providing a clearer picture of neuronal circuit dynamics at the mesoscopic level. [more]