Aging and Obesity
Aging & Obesity: central mechanisms and effects of nutrition & genetics on the brain
The world health organisation (WHO) classifies obesity as a major epidemic of the 21st century, underlining the importance of understanding both its determinants and consequences for public health policy. Obesity has been linked with abnormal functionality of homeostasis brain networks and changes in higher cognitive functions such as reward evaluation, executive functions and learning and memory. However, the underlying central mechanisms of obesity, and vice versa, how eating behaviour and other obesity-related factors affect brain structure and function, are far from understood.
Our goal is therefore threefold:
- to determine autonomic and cognitive control mechanisms that regulate food intake,
- to identify metabolic factors that impact the brain due to overeating and obesity or alternative eating habits, and
- to test if interventions that target these pathways could improve brain function.