Validation with histology of postmortem human tissue samples is an essential aspect of our work and we constantly strive to improve the validation techniques we employ. We investigate the effect of tissue preparation, such as tissue fixation, on MR contrast mechanisms. We adopt and further develop various histological methods, such as 3D histology, spatially-resolved mass spectrometry and ultra-high-resolution microscopy to obtain quantitative histological reference measures.

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Understanding brain development and decline is of utmost importance in an aging society. MRI Biophysics Research Group aims to uncover crucial mechanisms of human brain aging, by identifying the contribution of iron accumulation, a major determinant of brain development and brain decline. more

<span>Diffusion properties in cortical grey matter using inversion recovery diffusion weighted imaging</span>

Combined diffusion and T1 contrast can be used to explore the cortical grey matter structural complexity in the human brain in vivo. more

A Biophysical Model of Iron-Induced Transverse MRI Relaxation in Nigrosome 1: Toward an Early Biomarker of Parkinson's Disease

We linked the effective transverse relaxation rate R2* with dopaminergic cell densities and iron concentrations in nigrosome 1 by combining 3D quantitative iron histology, post mortem ultra-high resolution MRI, tissue deironing, and analytical modeling approaches. more

Relating layer-specific quantitative 7T MRI to histology, gene expression and connectomics

We investigate the relationship between quantitative MRI (qMRI) at different cortical depths and cell counts, gene expression and white matter connections in the brain in order to provide novel biomarkers for tracking neurodegenerative diseases. more

A multi-modal approach to in vivo U-fibre mapping in the early visual processing stream

Robust U-fibre connectivity mapping can be achieved in vivo in the early visual processing stream using combined diffusion weighted imaging and functional retinotopy more

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