Max Planck Institute for Human Cognitive and Brain Sciences
Validation with histology of postmortem human tissue samples is an essential aspect of our work and we constantly strive to improve the validation techniques we employ. We investigate the effect of tissue preparation, such as tissue fixation, on MR contrast mechanisms. We adopt and further develop various histological methods, such as 3D histology, spatially-resolved mass spectrometry and ultra-high-resolution microscopy to obtain quantitative histological reference measures.
We linked the effective transverse relaxation rate R2* with dopaminergic cell densities and iron concentrations in nigrosome 1 by combining 3D quantitative iron histology, post mortem ultra-high resolution MRI, tissue deironing, and analytical modeling approaches.
We investigate the relationship between quantitative MRI (qMRI) at different cortical depths and cell counts, gene expression and white matter connections in the brain in order to provide novel biomarkers for tracking neurodegenerative diseases.
We study the microanatomical properties of human white matter tracts with high-resolution light and electron microscopy with the goal to better interpret magnetic resonance imaging-based biophysical models of white matter properties.