Validation and Application
Lastly, we apply our latest methodological developments to fundamental neuroscientific research. We explore how cortical microarchitecture relates to genes and evolution. Our developments in optimized diffusion imaging and in optimized high-resolution functional imaging allow a detailed characterization of the visual system. By combining quantitative MRI with functional imaging methods, such as functional MRI and magnetoencephalography, we directly investigate the relationship between microstructure and information processing and transfer in the human brain. Finally, we aim to translate our methods to clinical applications, e.g., by providing quantitative outcome measures for clinical trials, such as the NISCI trial on spinal cord injury.
We used high-resolution fMRI and multivariate pattern analysis (MVPA) to explore how attentional modulation of working memory affects laminar specific representations in dorsolateral prefrontal cortex (dlPFC).
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We performed laminar fMRI during a delayed match-to-sample task and varied working memory load and the requirement for a motor response. We found layer specific univariate and multivariate effects.
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A recent fMRI study showed layer-specific responses in the dorsolateral prefrontal cortex during a working memory task. We attempted to replicate the original findings using newly acquired data and a fully automated analysis.
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Using a field strength of 7 Tesla, the "Arterial Blood Contrast" (ABC), which is based on the Magnetization Transfer effect, could be measured with an isotropic spatial resolution of 1.5 mm in combination with a conventional functional MRI contrast.
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In this project, we studied cortical myelin in living humans at the spatial scale of cortical columns using high-resolution quantitative magnetic resonance imaging (MRI) methods at 7 T.
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