Validation and Application

Lastly, we apply our latest methodological developments to fundamental neuroscientific research. We explore how cortical microarchitecture relates to genes and evolution. Our developments in optimized diffusion imaging and in optimized high-resolution functional imaging allow a detailed characterization of the visual system. By combining quantitative MRI with functional imaging methods, such as functional MRI and magnetoencephalography, we directly investigate the relationship between microstructure and information processing and transfer in the human brain. Finally, we aim to translate our methods to clinical applications, e.g., by providing quantitative outcome measures for clinical trials, such as the NISCI trial on spinal cord injury.

A Biophysical Model of Iron-Induced Transverse MRI Relaxation in Nigrosome 1: Toward an Early Biomarker of Parkinson's Disease

We linked the effective transverse relaxation rate R2* with dopaminergic cell densities and iron concentrations in nigrosome 1 by combining 3D quantitative iron histology, post mortem ultra-high resolution MRI, tissue deironing, and analytical modeling approaches. more

Relating layer-specific quantitative 7T MRI to histology, gene expression and connectomics

We investigate the relationship between quantitative MRI (qMRI) at different cortical depths and cell counts, gene expression and white matter connections in the brain in order to provide novel biomarkers for tracking neurodegenerative diseases. more

A multi-modal approach to in vivo U-fibre mapping in the early visual processing stream

Robust U-fibre connectivity mapping can be achieved in vivo in the early visual processing stream using combined diffusion weighted imaging and functional retinotopy more

Quantification of transverse relaxation times of human cortical and subcortical structures in vivo at 7T

Transverse relaxation parameters are quantified in vivo for different cortical structures of the human brain at ultra-high field strength. more

Differences in cortical and white matter myelination

We explore spatially resolved lipid imaging using matrix-assisted laser desorption/ionization (MALDI) as a method for validating MRI-based myelin biomarkers. more

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