Luettgau, L.; Schlagenhauf, F.; Sjoerds, Z.: Acute and past subjective stress influence working memory and related neural substrates. Psychoneuroendocrinology 96, pp. 25 - 34 (2018)
Understanding brain development and decline is of utmost importance in an aging society. MRI Biophysics Research Group aims to uncover crucial mechanisms of human brain aging, by identifying the contribution of iron accumulation, a major determinant of brain development and brain decline.
We linked the effective transverse relaxation rate R2* with dopaminergic cell densities and iron concentrations in nigrosome 1 by combining 3D quantitative iron histology, post mortem ultra-high resolution MRI, tissue deironing, and analytical modeling approaches.