Holiga, Š.: Personalizing functional magnetic resonance protocols for studying neural substrates of motor deficits in Parkinson’s disease. Dissertation (2013)
In this project, we investigate the brains of wild chimpanzees who died of natural causes at different developmental stages using high-resolution quantitative MRI and histology.
We used high-resolution fMRI and multivariate pattern analysis (MVPA) to explore how attentional modulation of working memory affects laminar specific representations in dorsolateral prefrontal cortex (dlPFC).
We performed laminar fMRI during a delayed match-to-sample task and varied working memory load and the requirement for a motor response. We found layer specific univariate and multivariate effects.
A recent fMRI study showed layer-specific responses in the dorsolateral prefrontal cortex during a working memory task. We attempted to replicate the original findings using newly acquired data and a fully automated analysis.
Using a field strength of 7 Tesla, the "Arterial Blood Contrast" (ABC), which is based on the Magnetization Transfer effect, could be measured with an isotropic spatial resolution of 1.5 mm in combination with a conventional functional MRI contrast.
In this project, we studied cortical myelin in living humans at the spatial scale of cortical columns using high-resolution quantitative magnetic resonance imaging (MRI) methods at 7 T.
In this project, we study the resolution limits of different high-resolution functional magnetic resonance imaging (fMRI) methods to resolve differences within the cerebral cortex.
We explore spatially resolved lipid imaging using matrix-assisted laser desorption/ionization (MALDI) as a method for validating MRI-based myelin biomarkers.
Embedded in the clinical trial NISCI (Nogo inhibition in spinal cord injury: www.nisci-2020.eu), we employ whole brain quantitative imaging at 3 Tesla as a new biomarker for de- and regeneration.
Columnar structures in the human visual cortex are studied using high-resolution fMRI methods in order to localize the actual source of neural processing more precisely.