We linked the effective transverse relaxation rate R2* with dopaminergic cell densities and iron concentrations in nigrosome 1 by combining 3D quantitative iron histology, post mortem ultra-high resolution MRI, tissue deironing, and analytical modeling approaches.
We investigate the relationship between quantitative MRI (qMRI) at different cortical depths and cell counts, gene expression and white matter connections in the brain in order to provide novel biomarkers for tracking neurodegenerative diseases.
Robust U-fibre connectivity mapping can be achieved in vivo in the early visual processing stream using combined diffusion weighted imaging and functional retinotopy
We characterize the cortical layers by biomechanical modeling and simulation of the developed human cortex tissue in-vivo using hyperelastic material models.
We explore spatially resolved lipid imaging using matrix-assisted laser desorption/ionization (MALDI) as a method for validating MRI-based myelin biomarkers.
We used high-resolution fMRI and multivariate pattern analysis (MVPA) to explore how attentional modulation of working memory affects laminar specific representations in dorsolateral prefrontal cortex (dlPFC).
Embedded in the clinical trial NISCI (Nogo inhibition in spinal cord injury: www.nisci-2020.eu), we employ whole brain quantitative imaging at 3 Tesla as a new biomarker for de- and regeneration.
We performed laminar fMRI during a delayed match-to-sample task and varied working memory load and the requirement for a motor response. We found layer specific univariate and multivariate effects.
In order to study the Basal Ganglia in relation to cortical areas, the used fMRI protocol has to be carefully adjusted with respect to its region of interest and the necessary signal under-sampling. We performed a study at a field strength of 7 Tesla investigating the dependence of the detected signal on the MR parameters employed.
A recent fMRI study showed layer-specific responses in the dorsolateral prefrontal cortex during a working memory task. We attempted to replicate the original findings using newly acquired data and a fully automated analysis.