Robust U-fibre connectivity mapping can be achieved in vivo in the early visual processing stream using combined diffusion weighted imaging and functional retinotopy
We characterize the cortical layers by biomechanical modeling and simulation of the developed human cortex tissue in-vivo using hyperelastic material models.
We explore spatially resolved lipid imaging using matrix-assisted laser desorption/ionization (MALDI) as a method for validating MRI-based myelin biomarkers.
We used high-resolution fMRI and multivariate pattern analysis (MVPA) to explore how attentional modulation of working memory affects laminar specific representations in dorsolateral prefrontal cortex (dlPFC).
Embedded in the clinical trial NISCI (Nogo inhibition in spinal cord injury: www.nisci-2020.eu), we employ whole brain quantitative imaging at 3 Tesla as a new biomarker for de- and regeneration.
We performed laminar fMRI during a delayed match-to-sample task and varied working memory load and the requirement for a motor response. We found layer specific univariate and multivariate effects.
In order to study the Basal Ganglia in relation to cortical areas, the used fMRI protocol has to be carefully adjusted with respect to its region of interest and the necessary signal under-sampling. We performed a study at a field strength of 7 Tesla investigating the dependence of the detected signal on the MR parameters employed.
A recent fMRI study showed layer-specific responses in the dorsolateral prefrontal cortex during a working memory task. We attempted to replicate the original findings using newly acquired data and a fully automated analysis.
We work on improving reliability of quantitative parametric maps by correcting for rigid head motion and B0-fluctuations measured during acquisition at 7T as well as by employing general function approximators to correct for artifacts of unknown origin at 3T.
Using a field strength of 7 Tesla, the "Arterial Blood Contrast" (ABC), which is based on the Magnetization Transfer effect, could be measured with an isotropic spatial resolution of 1.5 mm in combination with a conventional functional MRI contrast.
Columnar structures in the human visual cortex are studied using high-resolution fMRI methods in order to localize the actual source of neural processing more precisely.