We explore spatially resolved lipid imaging using matrix-assisted laser desorption/ionization (MALDI) as a method for validating MRI-based myelin biomarkers.
In this project, we investigate the brains of wild chimpanzees who died of natural causes at different developmental stages using high-resolution quantitative MRI and histology.
Using a field strength of 7 Tesla, the "Arterial Blood Contrast" (ABC), which is based on the Magnetization Transfer effect, could be measured with an isotropic spatial resolution of 1.5 mm in combination with a conventional functional MRI contrast.
DeepcomplexMRI deep learnig reconstruction has been modified to process multi-echo MRI images. First results for different undersampling strategies suggest that performance is comparable to modern iterative algorithms like ENLIVE while taking only about 5 minutes to reconstruct a full 3D 1mm³/voxel resolved head image stack.
In this project, we study the resolution limits of different high-resolution functional magnetic resonance imaging (fMRI) methods to resolve differences within the cerebral cortex.
Understanding brain development and decline is of utmost importance in an aging society. MRI Biophysics Research Group aims to uncover crucial mechanisms of human brain aging, by identifying the contribution of iron accumulation, a major determinant of brain development and brain decline.
We used high-resolution fMRI and multivariate pattern analysis (MVPA) to explore how attentional modulation of working memory affects laminar specific representations in dorsolateral prefrontal cortex (dlPFC).
Embedded in the clinical trial NISCI (Nogo inhibition in spinal cord injury: www.nisci-2020.eu), we employ whole brain quantitative imaging at 3 Tesla as a new biomarker for de- and regeneration.
We performed laminar fMRI during a delayed match-to-sample task and varied working memory load and the requirement for a motor response. We found layer specific univariate and multivariate effects.